Notch signals control the fate of immature progenitor cells in the intestine

Silvia Fre, Mathilde Huyghe, Philippos Mourikis, Sylvie Robine, Daniel Louvard and Spyros Artavanis-Tsakonas ()
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Silvia Fre: Massachusetts General Hospital Cancer Center
Mathilde Huyghe: Institut Curie-CNRS
Philippos Mourikis: Massachusetts General Hospital Cancer Center
Sylvie Robine: Institut Curie-CNRS
Daniel Louvard: Institut Curie-CNRS
Spyros Artavanis-Tsakonas: Massachusetts General Hospital Cancer Center

Nature, 2005, vol. 435, issue 7044, 964-968

Abstract: Alzheimer's drugs for cancer? Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers.

Date: 2005
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DOI: 10.1038/nature03589

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