The initiation of liver development is dependent on Foxa transcription factors

Catherine S. Lee, Joshua R. Friedman, James T. Fulmer and Klaus H. Kaestner ()
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Catherine S. Lee: Department of Genetics
Joshua R. Friedman: Department of Genetics
James T. Fulmer: Department of Genetics
Klaus H. Kaestner: Department of Genetics

Nature, 2005, vol. 435, issue 7044, 944-947

Abstract: Liver a little Foxa1 and Foxa2 regulatory proteins have been identified as essential for the specification of the cells that form the liver in the vertebrate embryo. Mouse embryos lacking these proteins are essentially liver-less, with no liver bud in the foregut endoderm. The Foxa genetic system may prove to be a useful model for the study of the molecular control of organogenesis in general, since as well as the liver, this part of the embryo forms the lungs, thyroid and pancreas.

Date: 2005
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DOI: 10.1038/nature03649

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