Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Johan H. van Es, Marielle E. van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J. Winton, Freddy Radtke and Hans Clevers ()
Additional contact information
Johan H. van Es: Netherlands Institute for Developmental Biology
Marielle E. van Gijn: Netherlands Institute for Developmental Biology
Orbicia Riccio: Ludwig Institute for Cancer Research
Maaike van den Born: Netherlands Institute for Developmental Biology
Marc Vooijs: Netherlands Institute for Developmental Biology
Harry Begthel: Netherlands Institute for Developmental Biology
Miranda Cozijnsen: Netherlands Institute for Developmental Biology
Sylvie Robine: Institut Curie-CNRS-UMR
Doug J. Winton: Cambridge Institute for Medical Research, Addenbrooke's Hospital
Freddy Radtke: Ludwig Institute for Cancer Research
Hans Clevers: Netherlands Institute for Developmental Biology

Nature, 2005, vol. 435, issue 7044, 959-963

Abstract: Alzheimer's drugs for cancer? Notch genes encode a range of membrane receptors that regulate cell-fate decisions by influencing communication between adjacent cells. Two groups now report the involvement of Notch signals in controlling the fate of intestinal epithelial tissue. In addition, blockade of the Notch pathway with the γ-secretase inhibitor DBZ halted growth of adenomas (polyps) in the small intestine and colon. Various γ-secretase inhibitors are being developed for the treatment of Alzheimer's disease; this new work suggests that they might also be used to treat colorectal cancers.

Date: 2005
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DOI: 10.1038/nature03659

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