In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Dorothy A. Sipkins (), Xunbin Wei, Juwell W. Wu, Judith M. Runnels, Daniel Côté, Terry K. Means, Andrew D. Luster, David T. Scadden and Charles P. Lin ()
Additional contact information
Dorothy A. Sipkins: Wellman Center for Photomedicine
Xunbin Wei: Wellman Center for Photomedicine
Juwell W. Wu: Wellman Center for Photomedicine
Judith M. Runnels: Wellman Center for Photomedicine
Daniel Côté: Wellman Center for Photomedicine
Terry K. Means: Massachusetts General Hospital East, Harvard Medical School
Andrew D. Luster: Massachusetts General Hospital East, Harvard Medical School
David T. Scadden: Massachusetts General Hospital, Harvard Medical School
Charles P. Lin: Wellman Center for Photomedicine

Nature, 2005, vol. 435, issue 7044, 969-973

Abstract: Comfortable cells The power of the latest microscopy techniques is demonstrated in a study of the vascular microenvironment in the bone marrow of mice. Confocal microscopy optimized for live animal imaging reveals that the tissue divides into discrete areas marked out by specialized endothelium. Molecules expressed in these domains mediate highly localized homing of the stem progenitor cells and lymphocytes needed for normal function of the bone marrow. But cancer cells — from an acute lymphoblastic leukaemia cell line, for instance — can also follow the trail to a welcoming microdomian. The vascular structures that create these inner spaces might therefore be potential targets for drugs designed to treat metastatic cancers.

Date: 2005
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DOI: 10.1038/nature03703

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