Stem cell division is regulated by the microRNA pathway

S. D. Hatfield, H. R. Shcherbata, K. A. Fischer, K. Nakahara, R. W. Carthew and H. Ruohola-Baker ()
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S. D. Hatfield: University of Washington
H. R. Shcherbata: University of Washington
K. A. Fischer: University of Washington
K. Nakahara: Northwestern University
R. W. Carthew: Northwestern University
H. Ruohola-Baker: University of Washington

Nature, 2005, vol. 435, issue 7044, 974-978

Abstract: Stem cell division The trademark property of stem cells is their capacity to multiply in tissues when other cells are quiescent. Somehow they by-pass the cell division stop signals. An experiment in which microRNA processing was blocked in Drosophila germline stem cells suggests that these gene-silencing regulatory molecules are part of a mechanism that makes stem cells insensitive to environmental signals that normally stop cells at the G1/S transition in the cell cycle. Without microRNAs, germ cells stop dividing just like ‘normal’ cells. Three papers in last week's Nature highlighted the role of microRNAs in human cancer: it is possible that the unregulated division of tumour cells and the regulation of stem cell division are two sides of the same microRNA coin. On the cover, stem cells lacking microRNAs stop dividing due to over-production of the tumour suppressor p21/p27.

Date: 2005
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DOI: 10.1038/nature03816

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