EphB receptor activity suppresses colorectal cancer progression

Eduard Batlle, Julinor Bacani, Harry Begthel, Suzanne Jonkeer, Alexander Gregorieff, Maaike van de Born, Núria Malats, Elena Sancho, Elles Boon, Tony Pawson, Steven Gallinger, Steven Pals and Hans Clevers ()
Additional contact information
Eduard Batlle: Center for Biomedical Genetics
Julinor Bacani: Mount Sinai Hospital
Harry Begthel: Center for Biomedical Genetics
Suzanne Jonkeer: Center for Biomedical Genetics
Alexander Gregorieff: Center for Biomedical Genetics
Maaike van de Born: Center for Biomedical Genetics
Núria Malats: Institut Municipal d'Investigació Mèdica
Elena Sancho: Center for Biomedical Genetics
Elles Boon: Academic Medical Center
Tony Pawson: Mount Sinai Hospital
Steven Gallinger: Mount Sinai Hospital
Steven Pals: Academic Medical Center
Hans Clevers: Center for Biomedical Genetics

Nature, 2005, vol. 435, issue 7045, 1126-1130

Abstract: Cancer progression The convergence between stem-cell and cancer-cell biology is well illustrated by a new study of colorectal cancer. A genetic program driven by β-catenin and Tcf is known to control stem-cell specification in the intestine and also to initiate colorectal cancer. EphB guidance receptors, widely studied in the context of axon guidance, are Tcf target genes involved in this pathway. The new work shows that most human colorectal cancers lose expression of EphB at the stage of transition between (benign) adenoma and (cancerous) carcinoma. Loss of EphB expression strongly correlates with degree of malignancy and in a mouse model, loss of EphB accelerates tumorigenesis in the colon and rectum. Loss of EphB expression is therefore a critical step in colorectal cancer progression.

Date: 2005
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DOI: 10.1038/nature03626

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