Ephrin signalling controls brain size by regulating apoptosis of neural progenitors

Vanessa Depaepe, Nathalie Suarez-Gonzalez, Audrey Dufour, Lara Passante, Jessica A Gorski, Kevin R. Jones, Catherine Ledent and Pierre Vanderhaeghen ()
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Vanessa Depaepe: University of Brussels
Nathalie Suarez-Gonzalez: University of Brussels
Audrey Dufour: University of Brussels
Lara Passante: University of Brussels
Jessica A Gorski: University of Colorado
Kevin R. Jones: University of Colorado
Catherine Ledent: University of Brussels
Pierre Vanderhaeghen: University of Brussels

Nature, 2005, vol. 435, issue 7046, 1244-1250

Abstract: Signalling brain size The mechanisms controlling brain size are central to developmental genetics, neurobiology and mammalian evolution. A new study shows that a class of signalling factors present in the developing brain, the ephrins, induces the death of the progenitor or stem cells that generate all neurons, and thereby control the final size of the cerebral cortex. When this ‘death signal’ is increased, brain size decreases, resulting in microcephaly. When it decreases, cortical size increases, leading to exencephalic brain overgrowth. This has implications for brain diseases, regeneration, and cancer.

Date: 2005
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DOI: 10.1038/nature03651

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