Escherichia coli swim on the right-hand side

Willow R. DiLuzio, Linda Turner, Michael Mayer, Piotr Garstecki, Douglas B. Weibel, Howard C. Berg and George M. Whitesides ()
Additional contact information
Willow R. DiLuzio: Harvard University
Linda Turner: The Rowland Institute at Harvard
Michael Mayer: Harvard University
Piotr Garstecki: Harvard University
Douglas B. Weibel: Harvard University
Howard C. Berg: The Rowland Institute at Harvard
George M. Whitesides: Harvard University

Nature, 2005, vol. 435, issue 7046, 1271-1274

Abstract: Right thinking bacteria This is a novelty. Escherichia coli cells tend to ‘drive on the right’. Swimming in shallow microchannels made of silicone rubber with soft agar floors, the flagellum-powered bacteria may experience less hydrodynamic drag when swimming closer to the bottom agar surface than to the top silicone surface, hence a preference for a certain position in the channel. Appropriate choice of channel wall materials can guide the motion of the cells, a first step towards the development of self-contained microdevices using moving bacterial cells for cell-based bioassays and biosensors.

Date: 2005
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DOI: 10.1038/nature03660

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