Dynamics of chronic myeloid leukaemia

Franziska Michor (), Timothy P. Hughes, Yoh Iwasa, Susan Branford, Neil P. Shah, Charles L. Sawyers and Martin A. Nowak
Additional contact information
Franziska Michor: Harvard University
Timothy P. Hughes: Institute of Medical and Veterinary Science
Yoh Iwasa: Kyushu University
Susan Branford: Institute of Medical and Veterinary Science
Neil P. Shah: Department of Medicine
Charles L. Sawyers: Department of Medicine
Martin A. Nowak: Harvard University

Nature, 2005, vol. 435, issue 7046, 1267-1270

Abstract: The kinetics of a cancer Chronic myeloid leukaemia is associated with the oncogene BCR-ABL. The tyrosine kinase inhibitor imatinib (Gleevec), in the news as the first molecularly targeted anticancer drug, acts by impairing the function of this oncogene. A study of 169 patients receiving imatinib followed the kinetics of BCR-ABL in order to develop a mathematical model of the in vivo kinetics of a cancer. Imatinib reduced the rate of leukaemic cell production, but did not appear to deplete a population of leukaemic stem cells. The model also indicates when multiple drug therapy might be more effective than imatinib alone.

Date: 2005
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DOI: 10.1038/nature03669

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