Global histone modification patterns predict risk of prostate cancer recurrence

David B. Seligson, Steve Horvath, Tao Shi, Hong Yu, Sheila Tze, Michael Grunstein and Siavash K. Kurdistani ()
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David B. Seligson: University of California
Steve Horvath: University of California
Tao Shi: University of California
Hong Yu: University of California
Sheila Tze: University of California
Michael Grunstein: University of California
Siavash K. Kurdistani: University of California

Nature, 2005, vol. 435, issue 7046, 1262-1266

Abstract: Histones in cancer Reports of altered epigenetic histone modifications in cancer cells have focused on individual gene promoters and so far none of these changes has been related to clinical outcome. Now aberrations of ‘global’ histone modification have been observed in prostate tumour patients. These do relate to clinical outcome, and suggest a useful means of prognosis.

Date: 2005
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DOI: 10.1038/nature03672

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