ATP is a mediator of chemosensory transduction in the central nervous system

Alexander V. Gourine (), Enrique Llaudet, Nicholas Dale and K. Michael Spyer
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Alexander V. Gourine: Royal Free and University College London Medical School
Enrique Llaudet: University of Warwick
Nicholas Dale: University of Warwick
K. Michael Spyer: Royal Free and University College London Medical School

Nature, 2005, vol. 436, issue 7047, 108-111

Abstract: Central casting ATP, the simple and evolutionarily ancient molecule ubiquitous in animals and plants as ‘portable energy’, is known to act in the peripheral nervous system, stimulating neurons in response to pain, touch and heat. Now a similar function for ATP has been discovered in the brain, where it is released from chemosensitive structures when the CO2 level in the blood is high and some serious breathing is required.

Date: 2005
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DOI: 10.1038/nature03690

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