Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse

Lara S. Collier, Corey M. Carlson, Shruthi Ravimohan, Adam J. Dupuy and David A. Largaespada ()
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Lara S. Collier: The University of Minnesota Twin Cities
Corey M. Carlson: The University of Minnesota Twin Cities
Shruthi Ravimohan: The University of Minnesota Twin Cities
Adam J. Dupuy: The University of Minnesota Twin Cities
David A. Largaespada: The University of Minnesota Twin Cities

Nature, 2005, vol. 436, issue 7048, 272-276

Abstract: Solid tumour screening Two papers this week report the use of a potent new mammalian genetic tool for understanding solid tumour formation. Until now forward genetic screening for cancer genes has been possible only in the haematopoietic system or mammary gland, using murine leukaemia viruses or mammary tumour viruses. The new method extends forward screening to solid tumours using the Sleeping Beauty transposon (jumping gene). If Sleeping Beauty slots into a chromosome near a potential cancer gene, tumour formation occurs and the gene can be identified.

Date: 2005
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DOI: 10.1038/nature03681

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