Blimp1 is a critical determinant of the germ cell lineage in mice

Yasuhide Ohinata, Bernhard Payer, Dónal O'Carroll, Katia Ancelin, Yukiko Ono, Mitsue Sano, Sheila C. Barton, Tetyana Obukhanych, Michel Nussenzweig, Alexander Tarakhovsky, Mitinori Saitou () and M. Azim Surani ()
Additional contact information
Yasuhide Ohinata: RIKEN Kobe Institute
Bernhard Payer: University of Cambridge
Dónal O'Carroll: The Laboratory for Lymphocyte Signaling
Katia Ancelin: University of Cambridge
Yukiko Ono: RIKEN Kobe Institute
Mitsue Sano: RIKEN Kobe Institute
Sheila C. Barton: University of Cambridge
Tetyana Obukhanych: The Rockefeller University
Michel Nussenzweig: The Rockefeller University
Alexander Tarakhovsky: The Laboratory for Lymphocyte Signaling
Mitinori Saitou: RIKEN Kobe Institute
M. Azim Surani: University of Cambridge

Nature, 2005, vol. 436, issue 7048, 207-213

Abstract: Abstract Germ cell fate in mice is induced in pluripotent epiblast cells in response to signals from extraembryonic tissues. The specification of approximately 40 founder primordial germ cells and their segregation from somatic neighbours are important events in early development. We have proposed that a critical event during this specification includes repression of a somatic programme that is adopted by neighbouring cells. Here we show that Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation. Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of homeobox genes that normally accompany specification of primordial germ cells. Furthermore, our genetic lineage-tracing experiments indicate that the Blimp1-positive cells originating from the proximal posterior epiblast cells are indeed the lineage-restricted primordial germ cell precursors.

Date: 2005
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DOI: 10.1038/nature03813

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