Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

Stefano Pluchino, Lucia Zanotti, Barbara Rossi, Elena Brambilla, Linda Ottoboni, Giuliana Salani, Marianna Martinello, Alessandro Cattalini, Alessandra Bergami, Roberto Furlan, Giancarlo Comi, Gabriela Constantin and Gianvito Martino ()
Additional contact information
Stefano Pluchino: Neuroimmunology Unit–DIBIT and
Lucia Zanotti: Neuroimmunology Unit–DIBIT and
Barbara Rossi: University of Verona
Elena Brambilla: Neuroimmunology Unit–DIBIT and
Linda Ottoboni: University of Verona
Giuliana Salani: Neuroimmunology Unit–DIBIT and
Marianna Martinello: University of Verona
Alessandro Cattalini: Neuroimmunology Unit–DIBIT and
Alessandra Bergami: Neuroimmunology Unit–DIBIT and
Roberto Furlan: Neuroimmunology Unit–DIBIT and
Giancarlo Comi: Vita-Salute University, San Raffaele Hospital
Gabriela Constantin: University of Verona
Gianvito Martino: Neuroimmunology Unit–DIBIT and

Nature, 2005, vol. 436, issue 7048, 266-271

Abstract: Stem cells steady the nerves The potential for stem-cell therapy in neurological disorders characterized by chronic inflammation, for example multiple sclerosis, brain tumours and ischaemic stroke, seems limited. Recurring inflammation is likely to destroy both resident and transplanted cells. But in a mouse model of chronic central nervous system inflammation, neural multipotent (stem) precursor cells have been found to promote neuroprotection by maintaining undifferentiated features and exerting unexpected immune-like functions. The undifferentiated cells survive repeated episodes of inflammation, suggesting that they could after all have therapeutic potential in these disorders.

Date: 2005
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DOI: 10.1038/nature03889

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