Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

Hideki Makinoshima and Michael S. Glickman ()
Additional contact information
Hideki Makinoshima: Sloan-Kettering Institute
Michael S. Glickman: Sloan-Kettering Institute

Nature, 2005, vol. 436, issue 7049, 406-409

Abstract: Tuberculosis target Many of the virulence determinants of Mycobacterium tuberculosis are lipids and glycolipids of the cell envelope. Now at last a mechanism that controls cell envelope composition — and in vivo pathogenesis — has been uncovered. It is regulated intramembrane proteolysis, a type of lipid regulation also used by mammals and bacteria. RIP may be an attractive pathway to target for development of new antituberculosis antibiotics.

Date: 2005
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature03713 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:436:y:2005:i:7049:d:10.1038_nature03713

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature03713

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().