EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus

Oscar A. Negrete, Ernest L. Levroney, Hector C. Aguilar, Andrea Bertolotti-Ciarlet, Ronen Nazarian, Sara Tajyar and Benhur Lee ()
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Oscar A. Negrete: Department of Microbiology, Immunology and Molecular Genetics
Ernest L. Levroney: Department of Microbiology, Immunology and Molecular Genetics
Hector C. Aguilar: Department of Microbiology, Immunology and Molecular Genetics
Andrea Bertolotti-Ciarlet: University of Pennsylvania
Ronen Nazarian: Department of Microbiology, Immunology and Molecular Genetics
Sara Tajyar: Department of Microbiology, Immunology and Molecular Genetics
Benhur Lee: Department of Microbiology, Immunology and Molecular Genetics

Nature, 2005, vol. 436, issue 7049, 401-405

Abstract: Nipah virus receptor Nipah virus, first recognized in 1999, is an emerging disease that causes fatal encephalitis in humans. Its natural host is thought to be the fruit bat but it is also found in pigs and other animals. It could pose a serious threat to the pig-farming industry and there is recent evidence of human-to-human transmission. A crucial receptor that the virus relies on to infect human cells has now been identified, suggesting ways that the infection might be countered by vaccines or drugs. The virus's attachment protein binds to the ephrinB2 receptor. This receptor is critical for normal vascular developmental processes and is present in tissues targeted by Nipah virus. The enzyme EphB4 can block the entry of the virus into the cell.

Date: 2005
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DOI: 10.1038/nature03838

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