Genes that mediate breast cancer metastasis to lung

Andy J. Minn, Gaorav P. Gupta, Peter M. Siegel, Paula D. Bos, Weiping Shu, Dilip D. Giri, Agnes Viale, Adam B. Olshen, William L. Gerald and Joan Massagué ()
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Andy J. Minn: Memorial Sloan-Kettering Cancer Center
Gaorav P. Gupta: Memorial Sloan-Kettering Cancer Center
Peter M. Siegel: Memorial Sloan-Kettering Cancer Center
Paula D. Bos: Memorial Sloan-Kettering Cancer Center
Weiping Shu: Memorial Sloan-Kettering Cancer Center
Dilip D. Giri: Memorial Sloan-Kettering Cancer Center
Agnes Viale: Memorial Sloan-Kettering Cancer Center
Adam B. Olshen: Memorial Sloan-Kettering Cancer Center
William L. Gerald: Memorial Sloan-Kettering Cancer Center
Joan Massagué: Memorial Sloan-Kettering Cancer Center

Nature, 2005, vol. 436, issue 7050, 518-524

Abstract: Abstract By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

Date: 2005
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DOI: 10.1038/nature03799

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