The Lyme disease agent exploits a tick protein to infect the mammalian host

Nandhini Ramamoorthi, Sukanya Narasimhan, Utpal Pal, Fukai Bao, Xiaofeng F. Yang, Durland Fish, Juan Anguita, Michael V. Norgard, Fred S. Kantor, John F. Anderson, Raymond A. Koski and Erol Fikrig ()
Additional contact information
Nandhini Ramamoorthi: Sections of Rheumatology
Sukanya Narasimhan: Sections of Rheumatology
Utpal Pal: Sections of Rheumatology
Fukai Bao: Sections of Rheumatology
Xiaofeng F. Yang: University of Texas Southwestern Medical Center
Durland Fish: Yale University School of Medicine
Juan Anguita: University of North Carolina at Charlotte
Michael V. Norgard: University of Texas Southwestern Medical Center
Fred S. Kantor: Allergy and Immunology, Department of Internal Medicine
John F. Anderson: Connecticut Agricultural Experiment Station
Raymond A. Koski: L2 Diagnostics
Erol Fikrig: Sections of Rheumatology

Nature, 2005, vol. 436, issue 7050, 573-577

Abstract: Can I borrow your coat? The Lyme disease spirochete has been found to take advantage of a tick protein in order to infect mice. The bacterium coats itself with a tick molecule that enables it to avoid host defences. If other vector-borne pathogens use this trick, it could provide a new target for therapeutics and vaccines.

Date: 2005
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DOI: 10.1038/nature03812

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