T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand

Kaushik Choudhuri, David Wiseman, Marion H. Brown, Keith Gould () and P. Anton van der Merwe ()
Additional contact information
Kaushik Choudhuri: University of Oxford
David Wiseman: University of Oxford
Marion H. Brown: University of Oxford
Keith Gould: Imperial College London
P. Anton van der Merwe: University of Oxford

Nature, 2005, vol. 436, issue 7050, 578-582

Abstract: T-cell receptor: small wonder The T cells patrol the body in search of unfamiliar molecules (antigens) that suggest the presence of harmful microorganisms. T-cell antigen receptors (TCRs) on the surface of T cells detect antigens presented on the surface of other cells by molecules of the MHC (major histocompatibility complex). Despite intensive study it is not known how TCR binding transmits a signal into the T-cell interior. New experiments suggest that the mechanism involves size-mediated segregation of the small TCR from the larger inhibitory molecules at the interface between the T cell and the cell that it is interacting with. The importance of the small size of the TCR-containing complex for TCR triggering raises the question of whether size has a role in signal transduction induced by other receptor–ligand interactions.

Date: 2005
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DOI: 10.1038/nature03843

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