Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants

Duo Wang, Scott Kennedy, Darryl Conte, John K. Kim, Harrison W. Gabel, Ravi S. Kamath, Craig C. Mello and Gary Ruvkun ()
Additional contact information
Duo Wang: Harvard Medical School
Scott Kennedy: Harvard Medical School
Darryl Conte: Program in Molecular Medicine
John K. Kim: Harvard Medical School
Harrison W. Gabel: Harvard Medical School
Ravi S. Kamath: Harvard Medical School
Craig C. Mello: Program in Molecular Medicine
Gary Ruvkun: Harvard Medical School

Nature, 2005, vol. 436, issue 7050, 593-597

Abstract: Abstract Caenorhabditis elegans homologues of the retinoblastoma (Rb) tumour suppressor complex specify cell lineage during development1,2. Here we show that mutations in Rb pathway components enhance RNA interference (RNAi) and cause somatic cells to express genes and elaborate perinuclear structures normally limited to germline-specific P granules. Furthermore, particular gene inactivations that disrupt RNAi reverse the cell lineage transformations of Rb pathway mutants. These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells.

Date: 2005
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DOI: 10.1038/nature04010

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