The hangover gene defines a stress pathway required for ethanol tolerance development

Henrike Scholz (), Mirjam Franz and Ulrike Heberlein ()
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Henrike Scholz: Department of Anatomy
Mirjam Franz: Biozentrum, University of Würzburg
Ulrike Heberlein: Department of Anatomy

Nature, 2005, vol. 436, issue 7052, 845-847

Abstract: Genetics of alcohol tolerance Improbable as it may seem, Drosophila fruit flies can be used as a model for alcohol-induced behaviours. Exposed to ethanol vapour in a device known as an inebriometer (it looks like a glass condenser), they lose control of their posture and sink to the bottom of the tube within 20 minutes. Repeated alcohol consumption leads to tolerance, but not in flies with a newly identified mutation. Flies with this hangover mutation also have a shortened life span and are more susceptible to stresses such as heat and insecticides. There is growing recognition that cellular and systemic stress contributes to drug- and addiction-related behaviours in mammals, and these studies suggest that this role may be conserved in evolution.

Date: 2005
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DOI: 10.1038/nature03864

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