Animal virus replication and RNAi-mediated antiviral silencing in Caenorhabditis elegans

R. Lu, M. Maduro, F. Li, H. W. Li, G. Broitman-Maduro, W. X. Li and S. W. Ding ()
Additional contact information
R. Lu: Institute for Integrative Genome Biology and Department of Plant Pathology
M. Maduro: Department of Biology
F. Li: Institute for Integrative Genome Biology and Department of Plant Pathology
H. W. Li: Institute for Integrative Genome Biology and Department of Plant Pathology
G. Broitman-Maduro: Department of Biology
W. X. Li: Institute for Integrative Genome Biology and Department of Plant Pathology
S. W. Ding: Institute for Integrative Genome Biology and Department of Plant Pathology

Nature, 2005, vol. 436, issue 7053, 1040-1043

Abstract: Super model for viruses The nematode Caenorhabditis elegans is an ideal model for the study of many aspects of cell biology, including the hot topic of RNA interference (RNAi). But there was a problem in using the worm to study antiviral RNAi responses: C. elegans seemed not to support viral replication. But now the insect pathogen Flock house virus and the mammalian pathogen vesicular stomatitis virus are both shown to infect the worm, and to provoke a strong RNAi-based antiviral defence. So this important genetic model is now available for the study of host–virus interactions, and the antiviral effect of RNAi.

Date: 2005
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DOI: 10.1038/nature03870

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