ERM is required for transcriptional control of the spermatogonial stem cell niche

Chen Chen, Wenjun Ouyang, Vadim Grigura, Qing Zhou, Kay Carnes, Hyunjung Lim, Guang-Quan Zhao, Silvia Arber, Natasza Kurpios, Theresa L. Murphy, Alec M. Cheng, John A. Hassell, Varadaraj Chandrashekar, Marie-Claude Hofmann, Rex A. Hess and Kenneth M. Murphy ()
Additional contact information
Chen Chen: Department of Pathology and Immunology
Wenjun Ouyang: Genentech
Vadim Grigura: Department of Pathology and Immunology
Qing Zhou: Washington State University
Kay Carnes: University of Illinois at Urbana–Champaign
Hyunjung Lim: Washington University School of Medicine
Guang-Quan Zhao: University of Texas Southwestern Medical School
Silvia Arber: University of Basel
Natasza Kurpios: McMaster University
Theresa L. Murphy: Department of Pathology and Immunology
Alec M. Cheng: Genentech
John A. Hassell: McMaster University
Varadaraj Chandrashekar: Southern Illinois University School of Medicine
Marie-Claude Hofmann: The University of Dayton
Rex A. Hess: University of Illinois at Urbana–Champaign
Kenneth M. Murphy: Department of Pathology and Immunology

Nature, 2005, vol. 436, issue 7053, 1030-1034

Abstract: Abstract Division of spermatogonial stem cells1 produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors2,3. Here we show that the Ets related molecule4 (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche.

Date: 2005
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DOI: 10.1038/nature03894

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