RNA interference is an antiviral defence mechanism in Caenorhabditis elegans

Courtney Wilkins, Ryan Dishongh, Steve C. Moore, Michael A. Whitt, Marie Chow () and Khaled Machaca ()
Additional contact information
Courtney Wilkins: Departments of Microbiology and Immunology
Ryan Dishongh: Departments of Microbiology and Immunology
Steve C. Moore: Departments of Microbiology and Immunology
Michael A. Whitt: University of Tennessee Health Science Center
Marie Chow: Departments of Microbiology and Immunology
Khaled Machaca: University of Arkansas for Medical Sciences

Nature, 2005, vol. 436, issue 7053, 1044-1047

Abstract: Super model for viruses The nematode Caenorhabditis elegans is an ideal model for the study of many aspects of cell biology, including the hot topic of RNA interference (RNAi). But there was a problem in using the worm to study antiviral RNAi responses: C. elegans seemed not to support viral replication. But now the insect pathogen Flock house virus and the mammalian pathogen vesicular stomatitis virus are both shown to infect the worm, and to provoke a strong RNAi-based antiviral defence. So this important genetic model is now available for the study of host–virus interactions, and the antiviral effect of RNAi.

Date: 2005
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DOI: 10.1038/nature03957

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