Adaptive immune responses in acute and chronic hepatitis C virus infection

David G. Bowen and Christopher M. Walker ()
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David G. Bowen: Center for Vaccines and Immunity, Columbus Children's Research Institute
Christopher M. Walker: Center for Vaccines and Immunity, Columbus Children's Research Institute

Nature, 2005, vol. 436, issue 7053, 946-952

Abstract: Abstract The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

Date: 2005
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DOI: 10.1038/nature04079

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