Hepatitis C and liver transplantation

Robert S. Brown ()
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Robert S. Brown: Columbia University College of Physicians and Surgeons

Nature, 2005, vol. 436, issue 7053, 973-978

Abstract: Abstract Liver transplantation is a life-saving therapy to correct liver failure, portal hypertension and hepatocellular carcinoma arising from hepatitis C infection. But despite the successful use of living donors and improvements in immunosuppression and antiviral therapy, organ demand continues to outstrip supply and recurrent hepatitis C with accelerated progression to cirrhosis of the graft is a frequent cause of graft loss and the need for retransplantation. Appropriate selection of candidates and timing of transplantation, coupled with better pre- and post-transplant antiviral therapy, are needed to improve outcomes.

Date: 2005
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DOI: 10.1038/nature04083

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