Aminoglycoside antibiotics induce bacterial biofilm formation

Lucas R. Hoffman, David A. D'Argenio, Michael J. MacCoss, Zhaoying Zhang, Roger A. Jones and Samuel I. Miller ()
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Lucas R. Hoffman: University of Washington
David A. D'Argenio: University of Washington
Michael J. MacCoss: University of Washington
Zhaoying Zhang: Rutgers University
Roger A. Jones: Rutgers University
Samuel I. Miller: University of Washington

Nature, 2005, vol. 436, issue 7054, 1171-1175

Abstract: Antibiotic-induced biofilms Bacteria commonly form adherent cell aggregates or biofilms in which they become resistant to killing by antibiotics. Now in a surprising development, commonly used aminoglycoside antibiotics at subinhibitory concentrations are shown to induce biofilm formation in Pseudomonas aeruginosa and Escherichia coli. Since most antibiotics are made by bacteria, such defences probably evolved as a result of microbial competition. A candidate antibiotic receptor that acts as a trigger for biofilm formation has been identified. Blocking this receptor could help to overcome antibiotic resistance and improve the efficacy of current therapy.

Date: 2005
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DOI: 10.1038/nature03912

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