Role of nucleophosmin in embryonic development and tumorigenesis

Silvia Grisendi, Rosa Bernardi, Marco Rossi, Ke Cheng, Luipa Khandker, Katia Manova and Pier Paolo Pandolfi ()
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Silvia Grisendi: Cancer Biology and Genetics Program
Rosa Bernardi: Cancer Biology and Genetics Program
Marco Rossi: Laboratory of Cellular Immunobiology
Ke Cheng: Cancer Biology and Genetics Program
Luipa Khandker: Cancer Biology and Genetics Program
Katia Manova: Memorial Sloan-Kettering Cancer Center
Pier Paolo Pandolfi: Cancer Biology and Genetics Program

Nature, 2005, vol. 437, issue 7055, 147-153

Abstract: A role for nucleophosmin Nucleophosmin is an oestrogen-regulated nucleolar protein that has been implicated in a number of cancers including myelodysplastic syndromes (MDS), a group of diseases characterized by overproduction of blood cells in the bone marrow. Now a role for nucleophosmin has been identified in normal cells: it is essential for normal embryonic development and, specifically, for the control of centrosome duplication and genomic stability. Loss of the Npm1 gene in mice produces features similar to those seen in MDS patients.

Date: 2005
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DOI: 10.1038/nature03915

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