Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance

Gerald Willimsky and Thomas Blankenstein ()
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Gerald Willimsky: Charité Campus Benjamin Franklin
Thomas Blankenstein: Charité Campus Benjamin Franklin

Nature, 2005, vol. 437, issue 7055, 141-146

Abstract: Duping the T cell Cancer immunosurveillance, the spontaneous recognition and elimination of tumours by T cells, is known to control certain virus-associated tumours but its role in the control of spontaneous tumours is a matter of some controversy. If immunosurveillance is involved, any immunogenic tumours that do eventually grow are likely to be escape variants, selected for low immunogenicity by T cells. A new transgenic mouse model in which sporadic tumours derive from a single cell and express a defined tumour-specific rejection antigen makes it possible to analyse the spontaneous immune response against tumours that develop slowly from single cells, thus reflecting physiological tumour development as closely as possible. Experiments on these mice suggest that there is no immunosurveillance: sporadic immunogenic tumours escape destruction by inducing T-cell tolerance, not by losing their intrinsic immunogenicity.

Date: 2005
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DOI: 10.1038/nature03954

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