Molecular insights into human brain evolution

Robert Sean Hill and Christopher A. Walsh ()
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Robert Sean Hill: Beth Israel Deaconess Medical Center
Christopher A. Walsh: Beth Israel Deaconess Medical Center

Nature, 2005, vol. 437, issue 7055, 64-67

Abstract: Abstract Rapidly advancing knowledge of genome structure and sequence enables new means for the analysis of specific DNA changes associated with the differences between the human brain and that of other mammals. Recent studies implicate evolutionary changes in messenger RNA and protein expression levels, as well as DNA changes that alter amino acid sequences. We can anticipate having a systematic catalogue of DNA changes in the lineage leading to humans, but an ongoing challenge will be relating these changes to the anatomical and functional differences between our brain and that of our ancient and more recent ancestors.

Date: 2005
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DOI: 10.1038/nature04103

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