Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

Abdolrahman S. Nateri, Bradley Spencer-Dene and Axel Behrens ()
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Abdolrahman S. Nateri: Mammalian Genetics Laboratory
Bradley Spencer-Dene: Lincoln's Inn Fields Laboratories
Axel Behrens: Mammalian Genetics Laboratory

Nature, 2005, vol. 437, issue 7056, 281-285

Abstract: Bowel cancer: JNK bonds A previously unknown link between the molecular pathways involving the transcription factors c-Jun and TCF4 may be important in bowel cancer development. Phosphorylated c-Jun interacts with TCF4 to form a complex that regulates gene promoters responsive to both WNT and JNK signalling. Blocking this interaction in the ApcMin mouse model of intestinal cancer delays tumorigenesis and reduces the number and size of tumours produced. It is particularly interesting that JNK may be a promising strategy to treat colon cancer, as small- molecule JNK inhibitors are already in clinical trials.

Date: 2005
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DOI: 10.1038/nature03914

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