A mechanistic principle for proton pumping by cytochrome c oxidase

Kristina Faxén, Gwen Gilderson, Pia Ädelroth and Peter Brzezinski ()
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Kristina Faxén: Stockholm University
Gwen Gilderson: Stockholm University
Pia Ädelroth: Stockholm University
Peter Brzezinski: Stockholm University

Nature, 2005, vol. 437, issue 7056, 286-289

Abstract: Pump it up The nature of proton pumping by cytochrome c oxidase, last link in the electron transfer chain in mitochondria and many bacteria, has been a reliable source of controversy over the years. Its mechanism of action is still something of a mystery, but a new study of proton pumping events in lipid vesicles containing a single molecule of the oxidase suggests a mechanism of action that could be generalized to all membrane-bound ion transporters.

Date: 2005
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DOI: 10.1038/nature03921

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