Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

Fernando Moreno-Herrero, Martijn de Jager, Nynke H. Dekker, Roland Kanaar, Claire Wyman () and Cees Dekker ()
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Fernando Moreno-Herrero: Delft University of Technology
Martijn de Jager: Department of Cell Biology and Genetics
Nynke H. Dekker: Delft University of Technology
Roland Kanaar: Department of Cell Biology and Genetics
Claire Wyman: Department of Cell Biology and Genetics
Cees Dekker: Delft University of Technology

Nature, 2005, vol. 437, issue 7057, 440-443

Abstract: Atherosclerosis induction Atherosclerotic plaques form when blood flow is disturbed and unusual patterns of mechanical stress are applied to the blood vessel wall. The endothelial cells lining these vessels play an important role in the development of the disease. A study using cultured aortic endothelial cells now shows that three proteins expressed in endothelial cells form a mechanosensory complex, and each one has distinct functions in transducing mechanical force into a biochemical signal inside the cell. This can explain how blood flow stimulates endothelial cell responses and how atherosclerotic plaques might be initiated.

Date: 2005
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DOI: 10.1038/nature03927

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