WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

Ivan B. Lobov, Sujata Rao, Thomas J. Carroll, Jefferson E. Vallance, Masataka Ito, Jennifer K. Ondr, Savita Kurup, Donald A. Glass, Millan S. Patel, Weiguo Shu, Edward E. Morrisey, Andrew P. McMahon, Gerard Karsenty and Richard A. Lang ()
Additional contact information
Ivan B. Lobov: University of Cincinnati
Sujata Rao: University of Cincinnati
Thomas J. Carroll: Harvard University
Jefferson E. Vallance: University of Cincinnati
Masataka Ito: National Defense Medical College
Jennifer K. Ondr: University of Cincinnati
Savita Kurup: University of Cincinnati
Donald A. Glass: Baylor College of Medicine
Millan S. Patel: Baylor College of Medicine
Weiguo Shu: University of Pennsylvania
Edward E. Morrisey: University of Pennsylvania
Andrew P. McMahon: Harvard University
Gerard Karsenty: Baylor College of Medicine
Richard A. Lang: University of Cincinnati

Nature, 2005, vol. 437, issue 7057, 417-421

Abstract: Abstract Macrophages have a critical role in inflammatory and immune responses through their ability to recognize and engulf apoptotic cells1. Here we show that macrophages initiate a cell-death programme in target cells by activating the canonical WNT pathway. We show in mice that macrophage WNT7b is a short-range paracrine signal required for WNT-pathway responses and programmed cell death in the vascular endothelial cells of the temporary hyaloid vessels of the developing eye. These findings indicate that macrophages can use WNT ligands to influence cell-fate decisions—including cell death—in adjacent cells, and raise the possibility that they do so in many different cellular contexts.

Date: 2005
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DOI: 10.1038/nature03928

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