Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

Rainer Zenz, Robert Eferl, Lukas Kenner, Lore Florin, Lars Hummerich, Denis Mehic, Harald Scheuch, Peter Angel, Erwin Tschachler and Erwin F. Wagner ()
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Rainer Zenz: Research Institute of Molecular Pathology
Robert Eferl: Research Institute of Molecular Pathology
Lukas Kenner: Research Institute of Molecular Pathology
Lore Florin: Division of Signal Transduction and Growth Control
Lars Hummerich: Deutsches Krebsforschungszentrum
Denis Mehic: Medical University of Vienna
Harald Scheuch: Research Institute of Molecular Pathology
Peter Angel: Division of Signal Transduction and Growth Control
Erwin Tschachler: Medical University of Vienna
Erwin F. Wagner: Research Institute of Molecular Pathology

Nature, 2005, vol. 437, issue 7057, 369-375

Abstract: Abstract Psoriasis is a frequent, inflammatory disease of skin and joints with considerable morbidity. Here we report that in psoriatic lesions, epidermal keratinocytes have decreased expression of JunB, a gene localized in the psoriasis susceptibility region PSORS6. Likewise, inducible epidermal deletion of JunB and its functional companion c-Jun in adult mice leads (within two weeks) to a phenotype resembling the histological and molecular hallmarks of psoriasis, including arthritic lesions. In contrast to the skin phenotype, the development of arthritic lesions requires T and B cells and signalling through tumour necrosis factor receptor 1 (TNFR1). Prior to the disease onset, two chemotactic proteins (S100A8 and S100A9) previously mapped to the psoriasis susceptibility region PSORS4, are strongly induced in mutant keratinocytes in vivo and in vitro. We propose that the abrogation of JunB/activator protein 1 (AP-1) in keratinocytes triggers chemokine/cytokine expression, which recruits neutrophils and macrophages to the epidermis thereby contributing to the phenotypic changes observed in psoriasis. Thus, these data support the hypothesis that epidermal alterations are sufficient to initiate both skin lesions and arthritis in psoriasis.

Date: 2005
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DOI: 10.1038/nature03963

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