Hoogsteen base-pairing in DNA replication? (reply)

Aneel Aggarwal (), Deepak Nair, Robert Johnson, Louise Prakash and Satya Prakash
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Aneel Aggarwal: Mount Sinai School of Medicine
Deepak Nair: Mount Sinai School of Medicine
Robert Johnson: Sealy Center for Molecular Science, University of Texas Medical Branch
Louise Prakash: Sealy Center for Molecular Science, University of Texas Medical Branch
Satya Prakash: Sealy Center for Molecular Science, University of Texas Medical Branch

Nature, 2005, vol. 437, issue 7057, E7-E7

Abstract: Abstract We have solved the crystal structure of human DNA polymerase-ι (hPolι) bound to a template primer and incoming nucleotide, and shown that hPolι uses Hoogsteen base-pairing for normal DNA synthesis1. Jimin Wang questions the space group we used and claims that Hoogsteen base-pairing is not supported by our electron-density maps2. We show here that the issue of space group does not affect our conclusions1 and that our electron-density maps are clear in indicating that Hoogsteen and not Watson–Crick base-pairing occurs in this situation.

Date: 2005
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DOI: 10.1038/nature04200

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