Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic

Frank Hsiung, Felipe-Andrès Ramirez-Weber, D. David Iwaki and Thomas B. Kornberg ()
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Frank Hsiung: University of California
Felipe-Andrès Ramirez-Weber: University of California
D. David Iwaki: University of California
Thomas B. Kornberg: University of California

Nature, 2005, vol. 437, issue 7058, 560-563

Abstract: Abstract The anterior/posterior (A/P) and dorsal/ventral (D/V) compartment borders that subdivide the wing imaginal discs of Drosophila third instar larvae are each associated with a developmental organizer. Decapentaplegic (Dpp), a member of the transforming growth factor-β (TGF-β) superfamily, embodies the activity of the A/P organizer. It is produced at the A/P organizer and distributes in a gradient of decreasing concentration to regulate target genes, functioning non-autonomously to regulate growth and patterning of both the anterior and posterior compartments1,2,3. Wingless (Wg) is produced at the D/V organizer and embodies its activity4,5. The mechanisms that distribute Dpp and Wg are not known, but proposed mechanisms include extracellular diffusion6, successive transfers between neighbouring cells7,8, vesicle-mediated movement9, and direct transfer via cytonemes10. Cytonemes are actin-based filopodial extensions that have been found to orient towards the A/P organizer from outlying cells. Here we show that in the wing disc, cytonemes orient towards both the A/P and D/V organizers, and that their presence and orientation correlates with Dpp signalling. We also show that the Dpp receptor, Thickveins (Tkv), is present in punctae that move along cytonemes. These observations are consistent with a role for cytonemes in signal transduction.

Date: 2005
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DOI: 10.1038/nature03951

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