DNA sequence and analysis of human chromosome 18

Chad Nusbaum (), Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Bruno Piqani, Cherylyn L Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakaki and Eric S. Lander
Additional contact information
Chad Nusbaum: Broad Institute of MIT and Harvard
Michael C. Zody: Broad Institute of MIT and Harvard
Mark L. Borowsky: Broad Institute of MIT and Harvard
Michael Kamal: Broad Institute of MIT and Harvard
Chinnappa D. Kodira: Broad Institute of MIT and Harvard
Todd D. Taylor: RIKEN Genomic Sciences Center
Charles A. Whittaker: Broad Institute of MIT and Harvard
Jean L. Chang: Broad Institute of MIT and Harvard
Christina A. Cuomo: Broad Institute of MIT and Harvard
Ken Dewar: Broad Institute of MIT and Harvard
Michael G. FitzGerald: Broad Institute of MIT and Harvard
Xiaoping Yang: Broad Institute of MIT and Harvard
Amr Abouelleil: Broad Institute of MIT and Harvard
Nicole R. Allen: Broad Institute of MIT and Harvard
Scott Anderson: Broad Institute of MIT and Harvard
Toby Bloom: Broad Institute of MIT and Harvard
Boris Bugalter: Broad Institute of MIT and Harvard
Jonathan Butler: Broad Institute of MIT and Harvard
April Cook: Broad Institute of MIT and Harvard
David DeCaprio: Broad Institute of MIT and Harvard
Reinhard Engels: Broad Institute of MIT and Harvard
Manuel Garber: Broad Institute of MIT and Harvard
Andreas Gnirke: Broad Institute of MIT and Harvard
Nabil Hafez: Broad Institute of MIT and Harvard
Jennifer L. Hall: Broad Institute of MIT and Harvard
Catherine Hosage Norman: Broad Institute of MIT and Harvard
Takehiko Itoh: Mitsubishi Research Institute Inc.
David B. Jaffe: Broad Institute of MIT and Harvard
Yoko Kuroki: RIKEN Genomic Sciences Center
Jessica Lehoczky: Broad Institute of MIT and Harvard
Annie Lui: Broad Institute of MIT and Harvard
Pendexter Macdonald: Broad Institute of MIT and Harvard
Evan Mauceli: Broad Institute of MIT and Harvard
Tarjei S. Mikkelsen: Broad Institute of MIT and Harvard
Jerome W. Naylor: Broad Institute of MIT and Harvard
Robert Nicol: Broad Institute of MIT and Harvard
Cindy Nguyen: Broad Institute of MIT and Harvard
Hideki Noguchi: RIKEN Genomic Sciences Center
Sinéad B. O'Leary: Broad Institute of MIT and Harvard
Bruno Piqani: Broad Institute of MIT and Harvard
Cherylyn L Smith: Broad Institute of MIT and Harvard
Jessica A. Talamas: Broad Institute of MIT and Harvard
Kerri Topham: Broad Institute of MIT and Harvard
Yasushi Totoki: RIKEN Genomic Sciences Center
Atsushi Toyoda: RIKEN Genomic Sciences Center
Hester M. Wain: University College London
Sarah K. Young: Broad Institute of MIT and Harvard
Qiandong Zeng: Broad Institute of MIT and Harvard
Andrew R. Zimmer: Broad Institute of MIT and Harvard
Asao Fujiyama: RIKEN Genomic Sciences Center
Masahira Hattori: RIKEN Genomic Sciences Center
Bruce W. Birren: Broad Institute of MIT and Harvard
Yoshiyuki Sakaki: RIKEN Genomic Sciences Center
Eric S. Lander: Broad Institute of MIT and Harvard

Nature, 2005, vol. 437, issue 7058, 551-555

Abstract: Secret Code The sequence of human chromosome 18, which has the lowest gene density of any human chromosome, is now complete. Surprisingly, the proportion of non-protein-coding regions evolutionarily conserved among mammals is close to the genome-wide average. This suggests that there is more to non-coding sequences than meets the eye, and that they are well worth holding on to.

Date: 2005
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DOI: 10.1038/nature03983

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