Pathogenic fungus harbours endosymbiotic bacteria for toxin production
Laila P. Partida-Martinez and
Christian Hertweck ()
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Laila P. Partida-Martinez: Leibniz Institute for Natural Products Research and Infection Biology, HKI
Christian Hertweck: Leibniz Institute for Natural Products Research and Infection Biology, HKI
Nature, 2005, vol. 437, issue 7060, 884-888
Abstract:
For fungal, read bacterial The antitumour agent rhizoxin is a fungal metabolite produced by Rhizopus microsporus, the pathogen that causes one of the most destructive diseases of rice crops, rice seedling blight. Or so we thought. Now it has been discovered that Rhizopus is not the true producer of rhizoxin. In fact it is synthesized by a bacterium of the genus Burkholderia, living in the fungus as an endosymbiont. Rhizoxin causes cell-cycle arrest in the plant cells, and the fungal pathogen and its symbiont both benefit from the decaying plant matter produced.
Date: 2005
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DOI: 10.1038/nature03997
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