Apolipoprotein-mediated pathways of lipid antigen presentation

Peter van den Elzen, Salil Garg, Luis León, Manfred Brigl, Elizabeth A. Leadbetter, Jenny E. Gumperz, Chris C. Dascher, Tan-Yun Cheng, Frank M. Sacks, Petr A. Illarionov, Gurdyal S. Besra, Sally C. Kent, D. Branch Moody and Michael B. Brenner ()
Additional contact information
Peter van den Elzen: Harvard Medical School
Salil Garg: Harvard Medical School
Luis León: Harvard Medical School
Manfred Brigl: Harvard Medical School
Elizabeth A. Leadbetter: Harvard Medical School
Jenny E. Gumperz: Harvard Medical School
Chris C. Dascher: Harvard Medical School
Tan-Yun Cheng: Harvard Medical School
Frank M. Sacks: Harvard School of Public Health
Petr A. Illarionov: The University of Birmingham
Gurdyal S. Besra: The University of Birmingham
Sally C. Kent: Harvard Medical School
D. Branch Moody: Harvard Medical School
Michael B. Brenner: Harvard Medical School

Nature, 2005, vol. 437, issue 7060, 906-910

Abstract: Immunity/lipids link An unexpected link between immunity and lipid metabolism has been found. Apolipoproteins critical in lipid trafficking during normal energy delivery and in atherosclerosis have been found to have a role in the immune system. Here they serve a special function in CD1-mediated presentation of lipid antigens for T-cell activation. This has implications for microbial immunity, autoimmunity and atherosclerosis.

Date: 2005
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DOI: 10.1038/nature04001

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