SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis

Stephen P. Grigg, Claudia Canales, Angela Hay and Miltos Tsiantis ()
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Stephen P. Grigg: University of Oxford
Claudia Canales: University of Oxford
Angela Hay: University of Oxford
Miltos Tsiantis: University of Oxford

Nature, 2005, vol. 437, issue 7061, 1022-1026

Abstract: Abstract Leaves of flowering plants are determinate organs produced by pluripotent structures termed shoot apical meristems. Once specified, leaves differentiate an adaxial (upper) side specialized for light capture, and an abaxial (lower) side specialized for gas exchange. A functional relationship between meristem activity and the differentiation of adaxial leaf fate has been recognized for over fifty years, but the molecular basis of this interaction is unclear. In Arabidopsis thaliana, activity of the class I KNOX (KNOTTED1-like homeobox) genes SHOOTMERISTEMLESS (STM) and BREVIPEDICELLUS (BP) is required for meristem function but excluded from leaves1,2,3, whereas members of the HD-Zip III (class III homeodomain leucine zipper) protein family function to promote both meristem activity and adaxial leaf fate4,5,6. Here we show that the zinc-finger protein SERRATE acts in a microRNA (miRNA) gene-silencing pathway to regulate expression of the HD-Zip III gene PHABULOSA (PHB) while also limiting the competence of shoot tissue to respond to KNOX expression. Thus, SERRATE acts to coordinately regulate meristem activity and leaf axial patterning.

Date: 2005
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DOI: 10.1038/nature04052

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