Vertebrate Smoothened functions at the primary cilium

Kevin C. Corbit, Pia Aanstad, Veena Singla, Andrew R. Norman, Didier Y. R. Stainier and Jeremy F. Reiter ()
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Kevin C. Corbit: Developmental and Stem Cell Biology Program
Pia Aanstad: Developmental and Stem Cell Biology Program
Veena Singla: Developmental and Stem Cell Biology Program
Andrew R. Norman: Developmental and Stem Cell Biology Program
Didier Y. R. Stainier: Developmental and Stem Cell Biology Program
Jeremy F. Reiter: Developmental and Stem Cell Biology Program

Nature, 2005, vol. 437, issue 7061, 1018-1021

Abstract: Cilia make sense The primary cilium is a mysterious organelle found on vertebrate cells in the interphase, the point in the cell cycle between two cell divisions when DNA is replicated and individual chromosomes are not distinguishable. The discovery that Smoothened, part of the Hedgehog signalling pathway, functions at the primary cilium supports the theory that the cilium acts as an antenna through which various signals are sensed and transduced. These signals may play an important role in development and disease.

Date: 2005
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DOI: 10.1038/nature04117

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