Isolation of drug-resistant H5N1 virus

Q. Mai Le, Maki Kiso, Kazuhiko Someya, Yuko T. Sakai, T. Hien Nguyen, Khan H. L. Nguyen, N. Dinh Pham, Ha H. Ngyen, Shinya Yamada, Yukiko Muramoto, Taisuke Horimoto, Ayato Takada, Hideo Goto, Takashi Suzuki, Yasuo Suzuki and Yoshihiro Kawaoka ()
Additional contact information
Q. Mai Le: National Institute of Hygiene and Epidemiology
Maki Kiso: Institute of Medical Science, University of Tokyo
Kazuhiko Someya: Institute of Medical Science, University of Tokyo
Yuko T. Sakai: Institute of Medical Science, University of Tokyo
T. Hien Nguyen: National Institute of Hygiene and Epidemiology
Khan H. L. Nguyen: National Institute of Hygiene and Epidemiology
N. Dinh Pham: National Institute of Hygiene and Epidemiology
Ha H. Ngyen: National Institute for Clinical Research in Tropical Medicine
Shinya Yamada: Institute of Medical Science, University of Tokyo
Yukiko Muramoto: Institute of Medical Science, University of Tokyo
Taisuke Horimoto: Institute of Medical Science, University of Tokyo
Ayato Takada: Institute of Medical Science, University of Tokyo
Hideo Goto: Institute of Medical Science, University of Tokyo
Takashi Suzuki: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi
Yasuo Suzuki: Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi
Yoshihiro Kawaoka: Institute of Medical Science, University of Tokyo

Nature, 2005, vol. 437, issue 7062, 1108-1108

Abstract: Resistant h5n1 The full report on an H5N1 avian flu virus isolate resistant to Tamiflu (oseltamivir) has added to concerns about preparations for a flu pandemic. The virus was from a Vietnamese girl given the drug as both prophylaxis and to treat infection. The discovery suggests it may be time to review dose rates for Tamiflu, and for governments to stockpile Relenza as well as Tamiflu.

Date: 2005
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DOI: 10.1038/4371108a

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