Wnt signalling regulates adult hippocampal neurogenesis

Dieter-Chichung Lie (), Sophia A. Colamarino, Hong-Jun Song, Laurent Désiré, Helena Mira, Antonella Consiglio, Edward S. Lein, Sebastian Jessberger, Heather Lansford, Alejandro R. Dearie and Fred H. Gage ()
Additional contact information
Dieter-Chichung Lie: The Salk Institute
Sophia A. Colamarino: The Salk Institute
Hong-Jun Song: The Salk Institute
Laurent Désiré: The Salk Institute
Helena Mira: The Salk Institute
Antonella Consiglio: The Salk Institute
Edward S. Lein: The Salk Institute
Sebastian Jessberger: The Salk Institute
Heather Lansford: The Salk Institute
Alejandro R. Dearie: The Salk Institute
Fred H. Gage: The Salk Institute

Nature, 2005, vol. 437, issue 7063, 1370-1375

Abstract: Wnt3 spells neuron Neural stem/progenitor cells in the adult brain are able to generate both the brain's major cell types: glial cells, which are non-neuronal, and the active nerve cells or neurons. Neurons are produced in just two regions of the brain. Lie et al. have now identified a protein family that instructs the adult neural stem cells to produce neurons, rather than glial cells. The signal molecule Wnt3 is shown to be crucial for the production of neurons in the adult hippocampus, a region believed to be involved in learning and memory formation. Ultimately these studies may help develop therapies to repair brain damage caused by disease or trauma.

Date: 2005
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DOI: 10.1038/nature04108

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