Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion

Ronald S. Veazey, Per Johan Klasse, Susan M. Schader, Qinxue Hu, Thomas J. Ketas, Min Lu, Preston A. Marx, Jason Dufour, Richard J. Colonno, Robin J. Shattock, Martin S. Springer and John P. Moore ()
Additional contact information
Ronald S. Veazey: Tulane National Primate Research Center
Per Johan Klasse: Weill Medical College of Cornell University
Susan M. Schader: Weill Medical College of Cornell University
Qinxue Hu: University of London
Thomas J. Ketas: Weill Medical College of Cornell University
Min Lu: Weill Medical College of Cornell University
Preston A. Marx: Tulane National Primate Research Center
Jason Dufour: Tulane National Primate Research Center
Richard J. Colonno: Bristol-Myers Squibb Pharmaceutical Institute
Robin J. Shattock: University of London
Martin S. Springer: Merck Research Laboratories
John P. Moore: Weill Medical College of Cornell University

Nature, 2005, vol. 438, issue 7064, 99-102

Abstract: Anti-HIV microbicide A trial of three inhibitors of HIV-1 entry into target cells, administered vaginally in macaque monkeys prior to intercourse, shows that they can protect against infection by a simian-human immunodeficiency virus. One molecule, the antiviral CMPD 167, is particularly potent, providing protection when applied 6 hours before challenge. The macaque model is a proven test of AIDS prevention strategies, so these findings bode well for the prospects of similar compounds in humans.

Date: 2005
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DOI: 10.1038/nature04055

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