A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression

Scott A. Rifkin, David Houle, Junhyong Kim () and Kevin P. White ()
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Scott A. Rifkin: Yale University
David Houle: Florida State University
Junhyong Kim: University of Pennsylvania, 203 Goddard Laboratories
Kevin P. White: Yale University

Nature, 2005, vol. 438, issue 7065, 220-223

Abstract: Evolve in haste... An experiment in twelve different strains of Drosophila suggests that naturally occurring mutations generate a large amount of gene expression variation at a surprisingly rapid rate. After only 200 generations of allowing natural mutations (with weak or no ill effects) to accumulate, gene expression evolution was detected in 40% of all genes. That variation has the potential to fuel evolution, yet comparison of the observed evolutionary rates with differences between species suggests that natural variation is constrained by physical, developmental, or some other factors.

Date: 2005
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DOI: 10.1038/nature04114

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