Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube

Yuko Muroyama, Yuko Fujiwara, Stuart H. Orkin () and David H. Rowitch ()
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Yuko Muroyama: Dana-Farber Cancer Institute
Yuko Fujiwara: Howard Hughes Medical Institute and Divisions of Hematology
Stuart H. Orkin: Dana-Farber Cancer Institute
David H. Rowitch: Dana-Farber Cancer Institute

Nature, 2005, vol. 438, issue 7066, 360-363

Abstract: Brain cell fates Astrocytes are one of three principal cell types that make up the brain, but surprisingly little is known about how these cells are formed during brain development. Now a protein called SCL, a basic helix–loop–helix transcription factor, is shown to instruct immature neural stem cells to become astrocytes. SCL is the first known protein with this role and understanding its function could provide insight into the contributions of astrocytes in human neurological diseases such as brain cancer, amyotrophic lateral sclerosis and Alzheimer's disease.

Date: 2005
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DOI: 10.1038/nature04139

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