Control of B-cell responses by Toll-like receptors

Chandrashekhar Pasare and Ruslan Medzhitov ()
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Chandrashekhar Pasare: Yale University School of Medicine
Ruslan Medzhitov: Yale University School of Medicine

Nature, 2005, vol. 438, issue 7066, 364-368

Abstract: Abstract Toll-like receptors (TLRs) detect microbial infection and have an essential role in the induction of immune responses1,2,3. TLRs can directly induce innate host defence responses, but the mechanisms of TLR-mediated control of adaptive immunity are not fully understood. Although TLR-induced dendritic cell maturation is required for activation of T-helper (TH) cells4, the role of TLRs in B-cell activation and antibody production in vivo is not yet known. Here we show that activation and differentiation of TH cells is not sufficient for the induction of T-dependent B-cell responses. We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells.

Date: 2005
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DOI: 10.1038/nature04267

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