Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler (), Sally C. Kent, Yahua Chen, Lisa Bregoli, Sue M. Clemmings, Bernhard Hering, Norma Sue Kenyon and Camillo Ricordi
Additional contact information
David A. Hafler: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School
Sally C. Kent: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School
Yahua Chen: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School
Lisa Bregoli: Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School
Sue M. Clemmings: University of Minnesota
Bernhard Hering: University of Minnesota
Norma Sue Kenyon: Diabetes Research Institute, Cell Transplant Center, University of Miami
Camillo Ricordi: Diabetes Research Institute, Cell Transplant Center, University of Miami

Nature, 2005, vol. 438, issue 7067, E5-E6

Abstract: Abstract Wilson discusses the avidity of the lymph-node T-cell clones we described1 that recognize the insulin A1–15 fragment. He questions whether large enough concentrations of insulin would be available in situ for antigenic stimulation of T cells2, given the amount of peptide required to stimulate the clones and their degree of responsiveness.

Date: 2005
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DOI: 10.1038/nature04424

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