Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, Julie A. Ellison, Eric E. Schadt, Inder M. Verma, David J. Lockhart and Carrolee Barlow ()
Additional contact information
Iiris Hovatta: Laboratory of Genetics
Richard S. Tennant: Laboratory of Genetics
Robert Helton: Laboratory of Genetics
Robert A. Marr: Laboratory of Genetics
Oded Singer: Laboratory of Genetics
Jeffrey M. Redwine: Neurome Inc.
Julie A. Ellison: Laboratory of Genetics
Eric E. Schadt: Merck & Co.
Inder M. Verma: Laboratory of Genetics
David J. Lockhart: Laboratory of Genetics
Carrolee Barlow: Laboratory of Genetics

Nature, 2005, vol. 438, issue 7068, 662-666

Abstract: The control of anxiety In conditions such as panic disorder, phobias and generalized anxiety disorder, an individual loses control of the fear and anxiety response, an important aid to survival when functioning normally. To learn more about the molecular and genetic basis for the regulation of the anxiety response, Hovatta et al. used a combination of behavioural testing in mice with gene expression profiling. They found two genes linked to anxiety: glyoxalase 1 and glutathione reductase. This establishes an association between anxiety and oxidative stress metabolism, and identifies potential biochemical pathways and molecular candidates for therapeutic intervention in anxiety disorders.

Date: 2005
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DOI: 10.1038/nature04250

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